Overview

• A University of South Australia team published peer‑reviewed findings in npj Antimicrobials and Resistance on interactions between common drugs and antibiotics.
• In laboratory experiments, E. coli exposed to ciprofloxacin with ibuprofen or paracetamol showed significantly higher mutation rates and resistance, with the strongest effect when the painkillers were combined.
• Genetic analyses indicated activation of bacterial defense mechanisms, including efflux systems that expel antibiotics and reduce their effectiveness.
• The study evaluated nine medications commonly used in residential aged care, highlighting polypharmacy as a potential driver of resistant gut bacteria.
• Authors and outside experts advise patients not to stop taking medicines, calling instead for further animal and clinical studies and for careful medication reviews in high‑risk settings.