Overview

• The analysis drew on anonymized electronic health records for 476,857 HG patients from 135 providers across 18 countries via the TriNetX network.
• Within a year of diagnosis, HG was associated with over 50% higher risk in 13 neuropsychiatric outcomes, including anxiety, PTSD, postpartum psychosis, and depression.
• Risks doubled for Wernicke’s encephalopathy, refeeding syndrome, eating disorders, and overall depression, with postpartum depression 2.7 times more likely than in non‑HG pregnancies.
• Cases coded as HG with metabolic disturbance showed a lower risk of depression than those labeled mild HG, suggesting physical severity does not reliably predict mental‑health burden.
• HG affects up to 3.6% of pregnancies and is the leading cause of first‑trimester hospitalization, and study authors from King’s College London call for clear referral pathways starting early in pregnancy.