Overview

• Kickoff is 1 p.m. ET at Highmark Stadium in Orchard Park on CBS, with local streaming available on Fubo where regional restrictions apply.
• Buffalo is 3-0 with the league leader in total offense and rushing, driven by Josh Allen, RB James Cook’s early breakout, and TE Dalton Kincaid’s steady role.
• The Saints are 0-3 with rookie QB Spencer Rattler over 600 passing yards and four touchdowns through three games, and their offense averaging under 16 points.
• Buffalo is a 14.5-point favorite and averaging 37.0 points per game, with a win positioning the team for its best start since opening 4-0 in 2020.
• Inactive lists include Bills DT Ed Oliver, LB Matt Milano, and RT Spencer Brown, while the Saints will be without DE Chase Young and several offensive linemen.