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HOPE Protocol Extends Donor Lung Preservation to Nearly 20 Hours

Clinical results presented at the ISHLT 2025 meeting confirm the safety and efficacy of the HOPE method, enabling longer preservation and improved transplant logistics.

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Overview

  • The hypothermic oxygenated machine perfusion (HOPE) protocol preserves donor lungs for up to 20 hours, surpassing the limits of traditional cold storage methods.
  • Clinical data from 12 HOPE cases showed no graft rejections and short-term outcomes comparable to 118 historical controls without ex vivo perfusion.
  • The protocol combines one hour of normothermic EVLP for lung assessment with continuous hypothermic perfusion at 12°C, eliminating the need for repeated ice storage.
  • Extended preservation windows allow for daytime transplant surgeries, reducing logistical challenges and potential surgical fatigue.
  • Future research will focus on tailoring preservation strategies to specific donor lung characteristics and exploring therapeutic interventions during extended perfusion.