High Niacin Levels Linked to Increased Heart Disease Risk, Study Finds

New research identifies a pathway through which excess niacin contributes to cardiovascular health issues, challenging previous assumptions about the vitamin's benefits.

A new study led by the Cleveland Clinic has found that high levels of niacin (vitamin B3) are linked to an increased risk of heart disease through a newly discovered pathway involving the metabolite 4PY.
4PY, a byproduct of excess niacin, directly triggers vascular inflammation, which can lead to atherosclerosis and other cardiovascular events.
The findings challenge previous beliefs about niacin's health benefits, particularly its use in lowering cholesterol and its fortification in foods.
Researchers suggest reevaluating niacin fortification in staple foods and caution against over-the-counter niacin supplements without medical consultation.
The study opens potential for new diagnostic and therapeutic approaches to counteract the effects of high niacin levels on cardiovascular health.