Overview

• The RAPID-RT study integrates a rapid-learning framework using anonymized real-world patient data to adapt and evaluate a heart-sparing radiotherapy technique.
• The technique limits radiation to a defined Cardiac Avoidance Area, capping doses to sensitive heart regions at 19.5 Gy over 20–33 sessions.
• Data from 1,708 patients were analyzed, with 786 treated with the heart-sparing method since April 2023, showing a modest 12-month survival improvement.
• The study’s inclusive design allowed nearly all eligible patients to participate, with only one opting out, reflecting its real-world applicability.
• Ongoing follow-up will assess long-term survival, toxicity reduction, and quality-of-life impacts to further validate these early findings.