Overview

• The Health Octo Tool quantifies biological age using eight physiological and biochemical domains, surpassing traditional aging metrics like epigenetic clocks and frailty indices.
• Developed by University of Washington researchers, the tool was validated across diverse populations and published in Nature Communications on May 5, 2025.
• The tool’s concept of 'health entropy' measures molecular and cellular damage to assess overall physical resilience and aging rate.
• Researchers are creating a digital application to track body and organ-specific biological ages, enabling real-time evaluation of lifestyle changes and treatments.
• Key findings highlight the significant long-term impact of early-life conditions, such as untreated hypertension, on biological aging, emphasizing the importance of early interventions.