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5d ago

Health Octo Tool Published, Validated as Breakthrough in Biological Aging Assessment

University of Washington researchers unveil an eight-domain framework that outperforms existing metrics in predicting disability and mortality risks, with a digital application under development.

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Overview

  • The Health Octo Tool, published in Nature Communications on May 5, 2025, integrates eight physiological and biochemical metrics to calculate biological aging rates.
  • Validated with data from the Baltimore Longitudinal Study on Aging and over 45,000 adults, the tool demonstrates superior accuracy compared to epigenetic clocks and frailty indices.
  • By identifying deviations in specific health domains, the tool enables personalized interventions targeting aging-related risks.
  • The framework is rooted in the concept of 'health entropy,' which quantifies accumulated molecular and cellular damage over time.
  • Researchers are developing a digital platform to allow individuals and clinicians to monitor biological aging and assess the impact of lifestyle changes and treatments.