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H3N2 ‘Subclade K’ Drives Early U.S. Flu Surge as Hospitalizations Climb

Health leaders recommend vaccination with early antivirals to reduce hospitalizations despite a partial vaccine mismatch.

Overview

  • CDC estimates now show about 4.6 million illnesses, 49,000 hospitalizations and 1,900 deaths this season, with a 14% weekly rise in hospitalizations in the latest report.
  • Nearly 90% of subtyped H3N2 samples belong to the K subclade that experts say can partly evade immunity, though available antivirals remain effective.
  • State and local data report sharp increases, including high or very high activity across Massachusetts, rising emergency visits in New York City, a December spike in Connecticut, and ER surges in Central Texas.
  • Officials emphasize that this year’s flu shot still reduces severe outcomes, with early U.K. estimates suggesting stronger protection for children than adults despite genetic drift.
  • Public guidance includes vaccination for everyone 6 months and older, prompt antiviral treatment within 1–2 days for high‑risk patients, staying home when sick, and hygiene and masking, with CDC surveillance updates delayed by the holidays.