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H3N2 K Variant Drives Early Flu Surge, Straining Hospitals Across the Northern Hemisphere

A partially vaccine-mismatched strain is driving hospital surges, prompting renewed precautions.

Overview

  • WHO reports the seasonal peak has arrived 3–6 weeks early, with sharp rises in cases and admissions in the UK, Germany, France, Italy, Spain, the US, Canada and Japan.
  • UK health authorities project up to about 8,000 influenza hospitalizations in England next week, a level not seen since 2010.
  • Hospitals and public agencies are reinstating measures such as masking in clinical settings, stay‑home and isolation advice for symptomatic people, surge staffing and targeted school disruptions.
  • Experts attribute the acceleration to H3N2 subclade K mutations that boost transmissibility and enable partial immune escape, as RSV and SARS‑CoV‑2 co-circulation complicates diagnosis.
  • Vaccination is still advised for strong protection against severe disease (roughly 65% effectiveness cited), and WHO and PAHO urge Southern Hemisphere countries to prepare, strengthen surveillance and plan earlier campaigns.