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H3N2 ‘K’ Drives Worsening U.S. Flu Season as New York Sets Weekly Record

Vaccination remains the primary safeguard as the CDC reports millions infected and urges early antivirals for high‑risk patients.

Overview

  • CDC surveillance indicates elevated influenza activity that continues to rise nationwide.
  • Season-to-date estimates exceed seven million illnesses, about 81,000 hospitalizations and roughly 3,100 deaths, with a sharp week-over-week jump in late December.
  • H3N2 subclade K now predominates in sequencing, showing high transmissibility without clear evidence of increased clinical severity.
  • New York reported 71,123 lab-confirmed cases in the week ending Dec. 20, the highest weekly total since 2004, and state hospitalizations rose 63% in the same span.
  • Argentina confirmed an imported H3N2 subclade K case in Mendoza in a 74-year-old traveler from Spain, verified by the Malbrán institute, and activated epidemiological monitoring with no community spread detected.