Overview

• Semaglutide and tirzepatide therapies have just become available in India, sparking rising demand for medical weight-loss solutions.
• The JAMA Internal Medicine guidance stresses that medication alone is insufficient and promotes tailored nutrition and physical activity to preserve muscle mass and improve adherence.
• Nutrition recommendations include starting each meal with 20–30 grams of protein and aiming for 1.0–1.5 grams per kilogram of body weight daily to support lean tissue.
• Experts outline dietary strategies to manage nausea, heartburn and constipation by choosing bland or fiber-rich foods, eating smaller portions and avoiding high-fat items.
• The exercise plan advises a gradual build-up from 10 minutes of daily moderate activity to 150 minutes weekly, plus 30-minute resistance-training sessions two to three times per week.