Groundbreaking Study Redefines APOE4 Gene’s Role in Alzheimer’s

Research now identifies the APOE4 gene variant as a direct cause of Alzheimer's, shifting its status from a risk factor to a primary driver of the disease.

Nearly all individuals with two copies of the APOE4 gene exhibit Alzheimer’s disease biomarkers by age 65, indicating a near-certain development of the condition.
The discovery challenges previous understanding and suggests that APOE4 homozygosity could define a distinct genetic form of Alzheimer's.
This finding could affect up to 10 million Americans, underscoring the need for targeted medical interventions and early monitoring.
Researchers advocate for immediate clinical trials and new treatment strategies to address this high-risk group.
Future studies are urged to consider genetic diversity, as the impact of APOE4 varies significantly across different ancestries.