Overview
- ABC has ordered 18 episodes for Season 22, marking the medical drama’s return to Thursday nights beginning October 16, 2025.
- Ellen Pompeo will appear in seven episodes as the series narrator while maintaining her executive producer role without resuming full-time acting duties.
- Core ensemble members such as Chandra Wilson, James Pickens Jr., Kevin McKidd, Camilla Luddington, Caterina Scorsone and Kim Raver are slated to return alongside Season 21 newcomer Trevor Jackson.
- Levi Schmitt (Jake Borelli) and Mika Yasuda (Midori Francis) are confirmed to depart the series after Season 21 concludes.
- Season 22 will resolve the cliffhanger that left Dr. Atticus “Link” Lincoln’s fate ambiguous following a hospital explosion.