Overview

• ABC has set the Season 22 premiere for October 16, 2025, at 10 P.M. ET.
• Showrunner Meg Marinis will oversee an 18-episode cycle that matches the previous season’s format.
• Ellen Pompeo will reprise her role as Meredith Grey in seven episodes and continue as executive producer and narrator.
• Only Meredith Grey and Ben Warren are confirmed to return, leaving Dr. Atticus “Link” Lincoln’s fate unclear after the Season 21 explosion.
• As of July 17, the series reclaimed the No. 1 spot on Disney+’s global streaming chart, surpassing MCU newcomer Ironheart.