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Grey's Anatomy Season 22 Premieres Tonight With Fallout From Hospital Explosion

The 18-episode run resumes seconds after the blast, setting up a milestone 450th episode.

Overview

  • Episode 1, “Only the Strong Survive,” airs Thursday at 10 p.m. ET on ABC, with next‑day streaming on Hulu and international availability on Disney+, while Canada’s CTV offers free next‑day streaming.
  • Showrunner Meg Marinis says the story picks up immediately after the Season 21 cliffhanger as Grey Sloan confronts a long road to recovery.
  • A recent trailer highlights severe consequences, and TV Insider reports six doctors remain in danger, while Jason George cautions that not everyone may survive the premiere.
  • Season 22 consists of 18 episodes, with Episode 2 marking the series’ 450th installment.
  • Ellen Pompeo returns on screen for seven episodes this season and continues to provide the show’s voiceover narration.