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Grey's Anatomy Season 22 Premiere Confronts Explosion Aftermath, Sets Stakes for What’s Next

The episode resolves the cliffhanger, establishing storylines shaped by lasting consequences for key characters.

Overview

  • The hour picks up immediately after the hospital blast, focusing on improvised rescue efforts and urgent triage.
  • Showrunner Meg Marinis said the writers weighed difficult outcomes to ensure the fallout carries real emotional weight.
  • A central surgeon endures severe injuries and begins a prolonged recovery arc that will influence relationships and work.
  • Ellen Pompeo returns in a prominent role as Meredith Grey as the series refocuses on core surgical storylines.
  • ABC confirms an 18-episode season, with the next episode marking the show's 450th installment.