Grey's Anatomy Season 21 Premieres with Major Cast Changes and High Stakes Drama

The long-running medical drama returns with Ellen Pompeo in a larger role, new showrunner Meg Marinis at the helm, and significant character exits and returns.

• Ellen Pompeo will appear in more episodes this season, after scaling back her role in previous seasons.
• Showrunner Meg Marinis promises an 18-episode season filled with rich character arcs and boundary-pushing storylines.
• Bailey, Amelia, Owen, and Teddy face job uncertainties after being let go from Grey Sloan Memorial, while Meredith negotiates their return.
• Midori Francis (Mika Yasuda) and Jake Borelli (Levi Schmitt) are set to exit the series, with their characters' storylines being honored.
• The season's theme centers on resilience, as characters navigate personal and professional challenges amidst ongoing medical crises.

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