Overview

• Season 22 debuts Thursday at 10 p.m. ET on ABC, streams Friday on Hulu, and rolls out internationally on Disney+ starting Oct. 10, with free next‑day streaming on CTV.ca in Canada.
• Showrunner Meg Marinis says the premiere picks up immediately after last season’s explosion, with ABC’s trailer highlighting the scramble to locate survivors.
• Promotional reporting identifies six doctors still in danger: Atticus “Link” Lincoln, Richard Webber, Monica Beltran, Jules Millin, Lucas Adams and Miranda Bailey.
• ABC confirms an 18‑episode run, with episode 2 on Oct. 16 serving as the series’ 450th installment.
• Core cast members return, including Ellen Pompeo, while Jake Borelli and Midori Francis have exited and Trevor Jackson expands his presence; cast teases describe the opener as intense and potentially deadly without revealing outcomes.