Overview

• The Season 22 opener resolves last season’s cliffhanger by confirming a fatality and detailing extensive injuries without revealing specific plot turns.
• Show leadership says the crisis will fuel a multi‑episode reconstruction of Grey Sloan and drive new personal and professional shifts for the ensemble.
• One doctor stabilizes after a close call and now faces a prolonged recovery that will keep them out of the operating room for some time.
• Meredith Grey appears more frequently this season as she returns to help steer the hospital through the rebuilding period.
• ABC set the season at 18 episodes, with Episode 2 marking the show’s 450th installment that continues the immediate aftermath.