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Gluteus Maximus Shape Tied to Sex-Specific Diabetes Patterns, Study Finds

Researchers using 3D MRI maps of 61,290 UK Biobank scans report shape features, not size, as potential metabolic markers pending further validation.

Overview

  • The team created detailed 3D models of the gluteus maximus to pinpoint localized structural changes beyond conventional volume or fat measures.
  • Among participants with type 2 diabetes, men showed focal inward deformation indicating localized shrinkage, whereas women showed outward expansion likely reflecting intramuscular fat.
  • Analysis across 86 demographic, clinical and lifestyle variables linked larger muscle shape to vigorous activity and grip strength, and associated thinning with aging, frailty and prolonged sitting.
  • Authors propose that muscle-shape signatures could enable earlier detection and monitoring of metabolic decline, though predictive value and clinical utility remain unproven.
  • The results are being presented at the RSNA annual meeting in Chicago from Nov. 30 to Dec. 4 as conference research rather than a peer-reviewed publication.