Overview

• Two Nature papers detail recordings from 139 mice capturing activity from more than 600,000 neurons across about 95% of the mouse brain.
• Analyses show that decision-making involves coordinated activity across many brain areas rather than a single control center.
• Researchers used Neuropixels probes during a visual steering-wheel task with sugar-water rewards to track brain activity from perception to action and reward.
• Varying stimulus visibility revealed the influence of prior knowledge on choices, with signals emerging early during decision formation.
• The International Brain Laboratory coordinated seven years of multi-lab work, and the full dataset—plus a subset of roughly 75,000 well-isolated neurons for detailed analysis—is publicly available.