Overview

• The Nature Aging study led by Maximilien Franck and Alan Cohen measured 19 cytokines in blood samples from cohorts in Italy, Singapore, the Bolivian Amazon and Malaysia to assess systemic inflammation patterns.
• In Italy and Singapore, inflammatory markers rose with age and mirrored higher rates of chronic conditions such as Alzheimer’s and diabetes, confirming inflammaging in industrialized settings.
• Among the Tsimane and Orang Asli, inflammation correlated with infection burden rather than aging, and chronic age-related diseases remained rare despite frequent infections.
• Study authors highlight diet, living conditions and environmental exposures as key modifiable influences on inflammation and recommend interventions tailored to specific population contexts.
• Epidemiologists Chiara Herzog and Ahmad Aziz warn that variations in marker selection, cohort demographics and reliance on self-reported health data warrant caution and further diverse research.