Overview

• The GNPC aggregated roughly 250 million protein measurements from over 35,000 blood and cerebrospinal fluid samples supplied by 23 research cohorts in the United States and Europe.
• Analyses published in Nature Medicine and Nature Aging identify an inflammation-related protein profile in APOE4 carriers that appears regardless of neurodegenerative diagnosis.
• Proteomic profiling uncovers both shared and unique biochemical fingerprints that distinguish Alzheimer’s, Parkinson’s, frontotemporal dementia and ALS and highlight different organ-specific aging patterns.
• Researchers say the newly identified protein signatures could enable blood-based diagnostics and monitoring tools to detect and track multiple brain diseases before clinical symptoms arise.
• The consortium has launched a phase 2 expansion to collect and analyze samples from underrepresented populations in South America, South Asia, Africa and Oceania.