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10h ago

Global Liver Cancer Cases to Surge by 2050, but Most Are Preventable

The Lancet Commission’s July report finds urgent prevention efforts could avert more than half of future liver cancer cases.

People sit at a bar in Manhattan on April 30, 2025 in New York.
Man holding stomach with pain at top right hand side.

Overview

  • The commission projects liver cancer incidence will climb from 870,000 new cases in 2022 to 1.52 million by 2050 driven by population growth and ageing.
  • At least 60% of liver cancer cases are linked to modifiable risk factors—hepatitis B and C, alcohol use and MASLD—and could be prevented through targeted interventions.
  • The share of cases from severe MASLD (MASH) is expected to rise from 8% to 11%, and alcohol-related cases from 19% to 21%, while HBV and HCV-related cancers decline.
  • Policy measures such as minimum alcohol unit pricing, sugar taxes and clear food labelling are recommended to curb the rising burden from alcohol and obesity.
  • Experts urge universal hepatitis B screening and routine liver damage assessments in primary care to boost early detection and save lives.