Overview

• Researchers at the Walter and Eliza Hall Institute published LoxCode in Cell on May 15, 2025, after developing a DNA barcoding cassette that records lineage in vivo.
• The system shuffles hundreds of millions of DNA segments into more than 30 billion unique barcodes to tag every cell in genetically engineered mice.
• Early LoxCode data revealed that cells in a few-hundred-cell embryo already split between full pluripotency and specific tissue commitments.
• Dedicated LoxCode mouse strains are now available through The Jackson Laboratory, enabling rapid deployment of the technology worldwide.
• Labs are applying LoxCode to questions in neuronal development, immune dynamics, organogenesis and the cellular origins of developmental disorders.