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12h ago

Global Genome Analysis Enables DNA-Based Stuttering Risk Prediction

Revealing 48 hereditary genes plus 57 genomic hotspots, the Nature Genetics report is guiding efforts to develop predictive DNA tests for stuttering risk in young children.

Image
Harriet Hewitt, ten, and her siblings are the fourth generation of their family to stutter
A young girl with blonde hair smiles for the camera.

Overview

  • The study, published in Nature Genetics, analyzed saliva samples from over one million participants, making it the largest genetic investigation of stuttering to date.
  • Researchers pinpointed 48 genes and 57 genomic regions associated with stuttering, confirming a strong inherited component to the speech disorder.
  • Genetic links between stuttering and traits such as emotional regulation, neurodiversity and musical rhythm suggest shared neurological pathways.
  • Investigators are now translating these markers into DNA-based screening tools designed to identify at-risk children before stutter symptoms emerge.
  • Early genetic risk prediction could enable targeted speech therapy, reducing bullying, discrimination and mental health challenges for the 400 million people who stutter worldwide.