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Genomic Analysis Shows Diphtheria Still Circulating After Western Europe’s Biggest Outbreak in 70 Years

Detected in Germany this year, a linked strain confirms the bacterium’s ongoing transmission.

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Vaccination is very effective against diphtheria, a highly contagious bacterial infection

Overview

  • The outbreak has tallied 536 confirmed infections and at least three fatalities across Western Europe since 2022.
  • Sequencing of 363 isolates shows 98% of cases occurred in males with a median age of 18, 96% of whom recently migrated from Afghanistan or Syria.
  • Cutaneous infections comprised 77% of cases while 15% presented severe respiratory symptoms, highlighting the pathogen’s diverse clinical risks.
  • Challenges in accessing and screening migrant and homeless populations have obscured the precise locations and full scale of transmission events.
  • Public health agencies are urging sustained cross-border surveillance, routine screening and maintained vaccination to close immunity gaps among vulnerable communities.