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Genome Survey Finds Heartworm Evolved With Wild Canids, Forming Regional Lineages

Analysis of more than 100 genomes clarifies patterns vital for tracking emerging drug resistance.

Overview

  • An international team led by University of Sydney researchers sequenced 100+ Dirofilaria immitis genomes from dogs and wild canids across multiple continents.
  • The study, published in Communications Biology, identifies distinct regional parasite populations shaped by ancient movements of wolves, dingoes and other canids.
  • Findings challenge the assumption that heartworm spread mainly through recent human transport of domestic dogs.
  • Australian heartworms show genetic links to Asian parasites, suggesting a possible dingo-era introduction, though a post‑colonial arrival cannot be ruled out.
  • Authors say regional genetic differences can inform surveillance and responses to emerging resistance, and they call for broader sampling to refine timelines and origins.