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Genetically Engineered Yeast Turns Urine Into Biocompatible Hydroxyapatite

The yeast platform could reduce treatment costs by harvesting urine nutrients to produce high-value hydroxyapatite.

A dental professional in surgical gloves and mask points to a model showing a dental implant integrated with natural teeth, under a clinical examination light. The image visually represents the application of hydroxyapatite in bone and dental implants—contextualizing the article's focus on converting human urine into implant-grade materials using synthetic yeast.
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Overview

  • Osteoyeast, a Saccharomyces boulardii strain engineered to mimic osteoblasts, yields hydroxyapatite from urine at up to one gram per kilogram.
  • Techno-economic modeling indicates production costs of about $19 per kilogram against potential market prices of $50 to $200, enabling profits exceeding $1 million annually for a city-scale facility.
  • The process recovers phosphorus and ammonia from wastewater streams, easing pollutant loads and lowering energy demands for treatment plants.
  • Hydroxyapatite produced is high-quality and biocompatible, suitable for medical implants and as a renewable alternative to plastics and construction materials.
  • The patented platform is now available for licensing with researchers exploring new yeast strains to sustainably produce other biobased materials.