Overview

• Researchers analyzed UK ICICLE and GLACIER cohorts comprising 2,169 women with DCIS and 185 with LCIS with a median follow-up of about 11 years.
• Among DCIS patients, those in the highest PRS313 quartile had roughly double the risk of contralateral invasive cancer compared with the lowest quartile, while ipsilateral risk was not significantly associated.
• In LCIS, higher PRS313 scores were linked to increased ipsilateral invasive cancer risk, reported as 2.16 times higher per unit increase in the score.
• Family history strengthened the LCIS association, with PRS313 increases tied to more than a threefold rise in ipsilateral risk, reaching about fourfold when excluding women treated with mastectomy and radiotherapy.
• The retrospective study, published in Cancer Epidemiology, Biomarkers & Prevention, suggests PRS-guided surveillance or preventive endocrine therapy could personalize management, though limited LCIS numbers and the score’s design for invasive disease necessitate further validation.