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Genetic Risk Score Flags Future Breast Cancer Risk After DCIS or LCIS

Researchers report a link to later invasive disease, cautioning that validation is needed before clinical use.

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Overview

  • The retrospective King’s College London analysis found PRS313 was associated with subsequent invasive breast cancer after diagnoses of ductal or lobular carcinoma in situ.
  • In DCIS, patients in the highest PRS313 quartile had about double the risk of contralateral cancer compared with those in the lowest quartile (2.03x).
  • In LCIS, higher PRS313 scores correlated with increased ipsilateral risk, estimated at 2.16-fold per rise in the score, though the smaller LCIS sample limits precision.
  • A reported family history amplified risk after LCIS, exceeding a threefold increase and approaching fourfold when patients with mastectomy or radiotherapy were excluded.
  • Findings come from the UK ICICLE and GLACIER cohorts (2,169 DCIS; 185 LCIS; median follow-up ~11 years) and were published Oct. 1 in Cancer Epidemiology, Biomarkers & Prevention, with authors noting the need for replication and clinical-utility studies.