Genetic Resilience More Crucial Than Diet in Lifespan Extension, Study Finds

Research on mice suggests that genetic factors outweigh dietary interventions like caloric restriction and intermittent fasting in determining longevity.

Researchers at The Jackson Laboratory studied nearly 1,000 genetically distinct mice on various diets to assess the impact on lifespan.
Caloric restriction was shown to extend lifespan more than intermittent fasting, but genetic factors played a larger role in longevity.
Mice that maintained weight and immune health despite caloric restriction lived longer, highlighting the importance of resilience.
Traditional markers of metabolic health, such as weight loss and glucose levels, were not strong indicators of lifespan extension.
The study suggests that human responses to dietary restrictions will vary significantly due to genetic differences.