Particle.news

Download on the App Store

Genetic Mutation in Mitochondrial DNA Identified as Potential ALS Trigger

Chinese researchers link a mitochondrial mutation to ALS, with experimental validation in animals and ongoing patient studies offering hope for new treatments.

Image
Image
Des scientifiques ont découvert une anomalie génétique dans l’ADN des mitochondries chez des patients atteints de la maladie de Charcot (photo d'illustration).

Overview

  • Scientists from China's Académie des sciences médicales have identified a mitochondrial DNA mutation potentially linked to ALS, a fatal neurodegenerative disease.
  • The mutation is believed to disrupt cellular respiration and impair motoneuron function, critical for muscle control.
  • Animal studies confirmed that introducing the mutation in healthy rats induced ALS-like symptoms, strengthening the case for its role in the disease.
  • Further patient-based analyses are underway to validate the findings and explore therapeutic strategies targeting mitochondrial dysfunction.
  • Researchers are optimistic that artificial intelligence could accelerate treatment development, potentially saving decades in research efforts.