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Genes and Auditory-Reward Disconnect Underlie Musical Anhedonia, Study Finds

A Trends in Cognitive Sciences review traces genetic causes alongside neural mechanisms of musical anhedonia by leveraging fMRI measurements, the Barcelona Music Reward Questionnaire plus twin study data.

Overview

  • People with musical anhedonia experience reduced communication between auditory processing areas and reward networks, as fMRI scans show diminished reward-circuit activation in response to music but normal responses to other stimuli.
  • The Barcelona Music Reward Questionnaire assesses five dimensions of music reward—emotion, mood regulation, social bonding, movement and novelty—and helps quantify individual differences.
  • A twin study suggests genetic factors account for up to 54 percent of the variability in how much pleasure people derive from music.
  • Ongoing collaborations with geneticists aim to identify specific genes linked to musical anhedonia and to determine whether the condition remains stable over the lifespan or can be reversed.
  • The research reframes reward processing as stimulus-specific and raises the possibility of discovering other forms of specific anhedonia across different sensory domains.