Gene Therapy Restores Hearing in Children with Hereditary Deafness

Innovative treatment shows promise in reversing hearing loss caused by OTOF gene mutations, offering new hope for affected families.

Five children regained hearing after receiving AAV-based gene therapy in both ears.
The therapy targets mutations in the OTOF gene, essential for transmitting sound signals.
Children showed improved speech perception and ability to locate sounds in noisy environments.
The trial, conducted in Shanghai and Boston, marks the first bilateral application of this therapy.
Researchers aim to expand trials and seek FDA approval for broader use.