Overview

• Healthy low-carbohydrate and low-fat diets rich in whole grains, fruits, vegetables, nuts and legumes were linked to a roughly 15% lower risk of coronary heart disease.
• Diet versions emphasizing refined grains, added sugars and animal products corresponded with elevated heart disease risk despite meeting macronutrient targets.
• The research pooled data from the Health Professionals Follow-Up Study, Nurses’ Health Study and Nurses’ Health Study II, tracking almost 200,000 participants from 1986 to 2019.
• Metabolomic profiling of over 10,000 participants highlighted how diet quality shapes metabolic pathways tied to cardiovascular health.
• Findings were unveiled at NUTRITION2025, the American Society for Nutrition’s annual meeting in Orlando.