Overview
- University of Nottingham researchers report a protein gel that recruits calcium and phosphate from saliva to drive epitaxial enamel-crystal growth integrated with existing tissue.
- In ex vivo studies on extracted human molars, a thin layer up to about 10 micrometers formed within roughly one to two weeks in saliva-like solutions and donated saliva.
- Regenerated surfaces showed near-native performance in tests simulating tooth brushing, chewing, and exposure to acidic foods.
- The work, published November 4 in Nature Communications, describes a fluoride-free material applied similarly to standard fluoride varnishes.
- The team’s startup, Mintech-Bio, plans first-in-human trials in early 2026 and is working toward an initial product timeline in 2026, with real-world durability and clinical efficacy still unproven.