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Flu Surges Nationwide as H3N2 Subclade K Dominates, Straining Hospitals Before Holidays

Officials say the drifted H3N2 offshoot only partly matches this season’s shot, which still reduces severe illness.

Overview

  • CDC estimates at least 4.6 million illnesses, 49,000 hospitalizations and 1,900 deaths so far this season.
  • Genetic testing shows roughly 90% of recent H3N2 samples belong to subclade K, now the dominant strain in U.S. circulation.
  • Fourteen states report high or very high respiratory illness levels, with New York flu hospitalizations jumping 75% in a week and some pediatric units at capacity.
  • Young children are bearing the brunt of illness, and three pediatric flu deaths have been reported to date.
  • Experts describe a partial vaccine mismatch but say shots still curb severe outcomes, urging vaccination, prompt antivirals within 48 hours, and basic precautions during holiday travel.