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Flu Surge Accelerates as H3N2 ‘Subclade K’ Becomes Dominant in U.S.

Early analyses indicate reduced vaccine match with sustained protection against hospitalization.

A student nurse practices the flu vaccination procedure in Montreal, Que. THE CANADIAN PRESS IMAGES/Lee Brown
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Sick young woman wrapped in a blanket, checking her temperature while sitting on a white sofa at home, seeking comfort and warmth during illness and recovery from a cold or flu

Overview

  • CDC estimates this season now total about 4.6 million illnesses, 49,000 hospitalizations and 1,900 deaths, including pediatric fatalities.
  • Genetic sequencing shows roughly 90% of sampled H3N2 viruses are the new subclade K, which is driving an earlier uptick in cases and hospital pressure.
  • U.K. data suggest the current vaccine cuts emergency visits or hospitalization by about 72–75% in children and 32–39% in adults despite the mismatch.
  • Doctors report antivirals such as oseltamivir and baloxavir remain effective, with strongest benefits when started early for high‑risk patients.
  • Health agencies urge vaccination for everyone 6 months and older plus basic precautions during holiday gatherings, as weekly reporting pauses until Dec. 30.