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3h ago

First Pig-to-Human Lung Transplant Functions for Nine Days in Brain-Dead Recipient

Experts call the brain-dead recipient study a proof of concept, not a treatment ready for patients.

In this photo provided by NYU Langone Health surgeons lower a gene-edited pig kidney into Lisa Pisano's abdomen at the hospital New York on April 12 2024. Doctors transplanted organ Pisano who was near death part of dramatic pair surgeries that also included fix for her failing heart. (Joe Carrotta/NYU via AP
primer trasplante de pulmón de cerdo a humano Foto Canva
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Overview

  • Guangzhou Medical University surgeons led by Jianxing He implanted a gene-edited Bama Xiang pig’s left lung into a 39-year-old man on May 15, 2024.
  • The graft showed no hyperacute rejection or infection initially, then developed severe pulmonary edema at 24 hours and antibody-mediated injury on days three and six, with partial recovery by day nine.
  • Observation ended at 216 hours at the family’s request, and the native right lung remained in place, limiting assessment of standalone function.
  • The donor pig, developed with Clonorgan Biotechnology, carried six edits (GTKO, B4GalNT2KO, CMAHKO, CD55, CD46, TBM) and the protocol used intensive multi-drug immunosuppression.
  • Researchers and outside experts say key hurdles include immune rejection, infection risk, organ preservation, and the need for more controlled studies before attempts in living patients.