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First Human West Nile Cases of 2025 Confirmed in Delaware County, Pa., and Massachusetts

Health officials warn of elevated risk through the fall, urging precautions until the first hard frost.

Overview

  • Delaware County confirmed its first human case this year, the sixth reported across the Philadelphia region, with no details released on the patient’s age, gender, or residence.
  • Massachusetts reported its first human infection of 2025 in a woman in her 70s who was exposed in Middlesex County, according to the state health department.
  • Surveillance remains elevated, with 108 West Nile–positive mosquito samples in Delaware County and 319 in Massachusetts across 12 of 14 counties.
  • Authorities advise EPA-registered repellents, long sleeves, avoiding dusk-to-dawn outdoor activity, and eliminating standing water, noting mosquitoes will persist until a hard frost.
  • Most infections are asymptomatic, about 20% cause flu-like illness, fewer than 1% lead to severe neurologic disease, and last year saw four deaths in the Philadelphia region.