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First Complete Old Kingdom Egyptian Genome Reveals North African and Fertile Crescent Origins

Analysis of DNA from a 4,800-year-old pot burial provides direct evidence of cross-regional gene flow in early Egypt

An ancient Egyptian ceramic pot excavated in 1902 at a site of rock-cut tombs at Nuwayrat, Egypt, is seen in this picture taken in 1902 and released on July 2, 2025. It contained the skeletal remains of a man who lived 4,500 to 4,800 years ago. Morez Jacobs, A. (2025)/Nature/Handout via REUTERS.
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The remains are now kept at World Museum Liverpool.
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Overview

  • Researchers extracted DNA from the teeth of a man interred in a ceramic pot at Nuwayrat and produced the first full genome from an Egyptian individual dating to the Old Kingdom period.
  • Genetic data show approximately 80% of his ancestry aligns with ancient North Africans while about 20% traces to early Fertile Crescent populations in Mesopotamia.
  • The pot burial predated mummification, creating stable conditions in tooth root tips that preserved DNA in an otherwise challenging arid environment.
  • Osteological analysis and chemical markers indicate the individual was a male in his mid-40s to mid-60s who grew up along the Nile and displayed skeletal features consistent with potter’s work.
  • Authors highlight the importance of sequencing additional ancient Egyptian genomes to map population variation and deepen understanding of early cultural exchanges.