Overview

• The birth of Amy Isabel in London marks the first successful uterus transplant birth in Britain, a major milestone in reproductive medicine.
• Grace, the 36-year-old mother, was born without a functional uterus due to Mayer-Rokitansky-Küster-Hauser syndrome.
• Her older sister, already a mother of two, donated her uterus to Grace in a transplant procedure conducted two years ago.
• Following the transplant, an embryo was implanted via artificial insemination, leading to the successful pregnancy and cesarean delivery in February 2025.
• This achievement builds on earlier breakthroughs in Sweden (2014) and Germany (2019), showcasing global progress in overcoming congenital infertility.