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3d ago

FDA Warns of Rare Severe Itching After Stopping Common Allergy Medications

Long-term use of Zyrtec and Xyzal linked to rare pruritus reaction, prompting updated safety labels and consumer guidance.

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Overview

  • The FDA has issued a safety warning about severe itching (pruritus) that can occur after discontinuing long-term daily use of cetirizine (Zyrtec) and levocetirizine (Xyzal).
  • Over 200 global cases of this rare reaction were identified between April 2017 and July 2023, often appearing within days of stopping the medications.
  • The FDA has updated prescribing information and requested warning labels for over-the-counter versions of these allergy drugs.
  • Manufacturers Opella and Sanofi have reaffirmed the safety of their products, emphasizing their efficacy when used as directed.
  • Health officials advise patients to consult their doctors if severe itching develops after stopping these medications, as symptoms may improve by resuming or tapering use.