Overview

• Brightly packaged tianeptine shots sold under names like Zaza, Tianaa and Neptune’s Fix continue to appear in gas stations, vape shops and online outlets despite lacking FDA approval.
• In June 2025 the FDA sent warning letters to distributors, placed tianeptine imports on alert and urged consumers to avoid these unregulated products.
• Poison control centers reported about 350 tianeptine-related exposures in 2024—up from four in 2013—with over half of recent cases requiring intensive care.
• States including Alabama saw a drop in emergency calls after banning or restricting tianeptine sales, illustrating the impact of local regulatory measures.
• Investigations in New Jersey uncovered tianeptine supplements laced with synthetic cannabinoids, raising alarms over mislabeled and potentially deadly formulations.