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FDA Fast-Tracks Augmentin XR in First Approval Under National Priority Voucher Pilot

The two-month review showcases an onshoring-focused pathway intended to strengthen antibiotic supply resilience.

Signage is seen outside of the Food and Drug Administration (FDA) headquarters in White Oak, Maryland, U.S., August 29, 2020. REUTERS/Andrew Kelly//File Photo

Overview

  • The FDA approved Augmentin XR under its Commissioner's National Priority Voucher pilot after an expedited review of roughly two months.
  • Regulators selected the application in part because manufacturing will occur at a U.S.-based facility to reinforce domestic capacity for essential medicines.
  • The agency said the decision is expected to help ease persistent antibiotic shortages that have disrupted care and encouraged broader-spectrum prescribing.
  • The CNPV pilot prioritizes applications aligned with national health goals such as manufacturing resilience, large unmet needs, innovation, and affordability, using a multidisciplinary review team and rapid sponsor communications.
  • Augmentin XR (amoxicillin–clavulanate) is indicated for community-acquired pneumonia and acute bacterial sinusitis and was originally approved in the U.S. in 1984, with this action setting a precedent for other voucher awardees.