Overview
- Osaka Metropolitan University scientists published the results in Bone & Joint Research, with contributions from Yuta Sawada and Dr. Shinji Takahashi.
- In 33 rats with osteoporosis-mimicking vertebral defects at L4–L5, groups received osteogenic ADSC spheroids, undifferentiated spheroids, or β‑tricalcium phosphate alone.
- The osteogenic spheroid–β‑tricalcium phosphate complex yielded superior bone regeneration on micro‑CT, stronger vertebrae on biomechanical tests, and upregulation of bone‑formation genes.
- Adipose‑derived stem cells are relatively easy to obtain, including from older donors, with minimal procedural burden.
- The work remains at the preclinical stage in animals and will need further validation and safety assessment before any human studies.