Overview

• Extracellular vesicles (EVs) facilitate specialized communication between different brain cell types during development.
• EVs carry proteins and transcription factors, such as YAP1, directly to the nucleus of recipient cells, inducing gene changes.
• The composition of EVs varies among different cell populations and brain regions, suggesting a tightly regulated biogenesis.
• High-resolution imaging shows EVs entering the nucleus of neural progenitor cells during cell division.
• These findings could pave the way for new therapeutic approaches to treat neurological diseases.