Overview

• The study published July 15 in Cell Genomics identified 282 extracellular vesicle transcripts that differ between lean and obese individuals.
• These EV RNAs correspond to regulatory elements and active genes in adipose tissue associated with body mass index and type 2 diabetes.
• Differential EV-RNA profiles are driven chiefly by vesicles released from diverse adipose cell types.
• Researchers optimized adipose explant culture and EV isolation methods and integrated transcriptomic data with GWAS, TWAS and PheWAS analyses.
• Follow-up work will examine how these EV transcripts change after bariatric surgery or GLP-1 agonist treatment and how adipose EVs signal to other organs.